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KMID : 0379520200360030227
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한국독성학회지
2020 Volume.36 No. 3 p.227 ~ p.238
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Ameliorative effect of aqueous leaf extract of Solanum aethiopicum on phenylhydrazine-induced anaemia and toxicity in rats
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Ekweogu Celestine Nwabu
Ude Victor Chibueze
Nwankpa Promise
Emmanuel Okezie
Ugbogu Eziuche Amadike
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Abstract
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Solanum aethiopicum is used in ethnomedicine for the treatment of overweight, constipation and anaemia. This study evaluated the ameliorative effect of aqueous leaf extract of S. aethiopicum on phenylhydrazine-induced anaemia in rats. Acute toxicity was determined in male and female rats (n?=?5/group/sex) by oral administration of single dose of up to 5000 mg/kg of the S. aethiopicum extract. The experimental rats were randomly grouped into five (5) groups of 6 rats each. Group (i) served as normal control, group (ii) negative control, group (iii) standard drug-5 mg/kg ferrous sulphate, groups (iv) and (v), 200 and 400 mg/kg of S. aethiopicum extract respectively. Phenylhydrazine (PHZ) was administered intraperitoneally at the dose of 50 mg/kg body weight for two consecutive days to groups (ii?v). After 14 days, the rats were sacrificed; blood, liver and kidney were collected. The haematological, lipid profile, liver and kidney function parameters were determined and the histopathology of the liver and kidney were examined. In acute toxicity study, no signs of toxicity or death were recorded. The study shows an observable significant (P?
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KEYWORD
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Solanum aethiopicum, Toxicity, Anaemia, Liver and kidney, Haematology
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